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As a result, this exchange revenue bears little relationship to the recognized cost of MMS and cannot be matched against its gross cost of operations.
Large-scale sequence analysis of this region between human and chimpanzee will be necessary to refine the exact position of the pericentric inversion.
See March Comments at 74 (comment of Keith S. Ernst, Attorney at Law); March Comments at 201 (comment of Jose Padilla and Cynthia L. Rice, California Rural Legal Assistance); April Testimony at 21 (testimony of Cynthia Rice, California Rural Legal Assistance).
The authors thankfully acknowledge support by the training grant 1-T15-LM07438-01 "training of toolmakers for Biomedical Informatics" by the National Library of Medicine of the National Institutes of Health, USA (NLM/NIH, http://www.nlm.nih.gov/ep/T15Training.html).
Previously it has been shown that a targeting vector, pMP8, can correct the loss of Hprt activity in E14TG2a ES cells that lack exons 1 and 2 of the hprt gene [ 2 15 ] . The design of this vector implied that it should also be capable of correcting the hprt exon 1 deficiency in F3 cells and could, therefore, be used to introduce transgenes into the hprt locus by homologous recombination.